S.E.M.I.: Side Effects May Include...
S.E.M.I.: Side Effects May Include... came out on January 23, 2026 on PC. It is developed and published by Two Horn Unicorn.
Last checked · Source: IGDB, official site
Key facts
- Release date
- January 23, 2026
- Platforms
- PC
- Developer
- Two Horn Unicorn
- Publisher
- Two Horn Unicorn
- Genres
- Hack and slash/Beat 'em up, Indie, Arcade
- Links
- Official siteSteam
How much is S.E.M.I.: Side Effects May Include...?
$7.99
On Steam (US store).
Source: Steam, checked . Base game on Steam’s US store; editions, other platforms and other regions can be priced differently.
S.E.M.I.: Side Effects May Include... PC system requirements
| Component | Minimum | Recommended |
|---|---|---|
| OS | MinimumWindows 10 | RecommendedWindows 11 |
| Processor | MinimumIntel Core i5 series or Ryzen series | RecommendedIntel Core i7 series or Ryzen series |
| Memory | Minimum8 GB RAM | Recommended8 GB RAM |
| Graphics | MinimumGTX 960 or AMD R9 290 | RecommendedGTX 1660 or RX6600 |
| DirectX | MinimumVersion 11 | RecommendedVersion 12 |
| Storage | Minimum3 GB available space | Recommended3 GB available space |
- Requires a 64-bit processor and operating system
- Languages (9)
- English, Russian, French, German, Spanish - Spain, Simplified Chinese, Portuguese - Brazil, Japanese, Korean
- Controller support
- Full controller support
- On Steam for
- Windows
Source: Steam store page, checked . Requirements can change before and after launch; Steam’s page is the current word.
About S.E.M.I.: Side Effects May Include...
S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.
Storyline
S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.
Screenshots
S.E.M.I.: Side Effects May Include...: common questions
Answered from the data on this page: IGDB, last checked November 2, 2026, and Steam or other sources where an answer names them.
When did S.E.M.I.: Side Effects May Include... come out?
S.E.M.I.: Side Effects May Include... came out on January 23, 2026 on PC.
Is S.E.M.I.: Side Effects May Include... out yet?
Yes. S.E.M.I.: Side Effects May Include... came out on January 23, 2026 on PC.
How much does S.E.M.I.: Side Effects May Include... cost?
S.E.M.I.: Side Effects May Include... costs $7.99 on Steam (US store), as of November 2, 2026. Prices on other platforms and in other regions can differ.
What platforms is S.E.M.I.: Side Effects May Include... on?
S.E.M.I.: Side Effects May Include... is available on PC.
Is S.E.M.I.: Side Effects May Include... on PC?
Yes. PC is currently its only confirmed platform.
What are the S.E.M.I.: Side Effects May Include... PC requirements?
Steam lists the minimum PC spec for S.E.M.I.: Side Effects May Include... as Intel Core i5 series or Ryzen series, 8 GB RAM and GTX 960 or AMD R9 290, with 3 GB available space. The recommended spec is Intel Core i7 series or Ryzen series, 8 GB RAM and GTX 1660 or RX6600. The full minimum and recommended table is in the PC system requirements section above.
Who is making S.E.M.I.: Side Effects May Include...?
S.E.M.I.: Side Effects May Include... is developed and published by Two Horn Unicorn.
Our coverage
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